Heart failure is associated with low circulating levels of secreted frizzled receptor protein 5 (Sfrp5)

Abstract Background/Introduction Obesity and metabolic dysregulation are closely associated with the pathophysiology of multiple cardiovascular diseases (CVD). To date, pathophysiological mechanism(s) obesity its link systems remain largely unknown. Adipose tissue inflammation as a result excessive fat expansion in obesity, leading to increased systemic production growth factors recruitment inflammatory cells have been postulated be major factor. Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that linked regulation has indicated affect functions. Currently, role circulating SFRP5 levels biomarker for poorly understood, studies yielding discordant results. Purpose This study aims evaluate relationship between functions cohort patients established CVD. Methods Patients (n=262, 148 male (56.5%), age (68±11 yrs)) presenting cardiology unit investigations were recruited into study. Plasma measured via enzyme-linked immunosorbent assay (ELISA). Associations plasma levels, functions, patients' co-morbidities analysed using univariate multivariate analyses. Results significantly lower with: heart failure (HF) vs non-HF (median; (10.7 31.0; p<0.001); coronary artery disease (CAD) non-CAD; (11.0 33.8; atrial fibrillation (AF) non-AF; (11.2 23.2; p=0.001). On analyses, also positively correlated left ventricular ejection fraction (LVEF) (r=0.52, p<0.001), estimated glomerular filtration rate (eGFR) (r=0.16, p=0.02), total cholesterol triglycerides (r=0.29, p<0.001; r=0.17, p<0.01 respectively). Low high C-reactive (CRP) E/E' (r=−0.29, p<0.001, r=−0.30, HF, CAD, statin use, low LVEF, triglycerides, CRP eGFR independent age, BMI or diabetes on analysis (overall model r=0.729, SE=0.638). Conclusion Our results show independently impaired systolic diastolic These suggest may regulate regulations. Funding Acknowledgement Type funding sources: Private grant(s) and/or Sponsorship. Main source(s): Heart Foundation Australia Future Leader FellowshipsNSW Ministry Health EMC FellowshipHeart Fellowship